Carbohydrate-carbohydrate interaction as an initial step in cell recognition
نویسنده
چکیده
Specific interaction between specific carbohydrate moieties of glycosphingolipids (GSLs) has been demonstrated based on interaction of GSLcontaining liposomes with GSL-coated solid phase, and affinity adsorption of multivalent GSL oligosaccharide on solid-phase GSL column. Evidence is presented that such GSL-GSL interaction is an initial step in the cell recognition process. Examples are LeX-LeX interaction at the morula stage of mouse embryogenesis, Gg3-GM3 interaction in melanoma/lymphoma cell interaction, and galactosylceramide-sulfatide interaction in myelin sheath membrane formation. The molecular basis of such interactions is discussed.
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